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Metonitazene CAS No. 14680-51-4

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Chemical Name: Metonitazene
Molecular Formula: C21H26N4O3
Formula Weight: 382.46
CAS No.: 14680-51-4
Synonyms: Metonitazene;(4-methoxyphenyl)methyl;Metonitazen


Only for research, not for human or veterinary use.

Metonitazene(CAS No.: 14680-51-4) is an analgesic drug related to etonitazene. In vitro studies of metonitazene’s activity at the mu-opioid receptor have found it to be between 113-121% that of fentanyl, and 184-340% that of hydromorphone.  Not surprisingly, metonitazene produces robust typical mu-opioid receptor agonist pharmacodynamic effects.

The analgesic effects of metonitazene have been studied in preclinical models, indicating a potency of between 30-200 times that of morphine (depending on the administration route and animal model).


Given its chemical properties, metonitazene could lend itself to recreational use through intranasal, smoking, and intravenous means.   



Metonitazene is lipophilic, as are its homologues etonitazene and isonitazene.

The calculated octanol/water distribution coefficient for metonitazene is logP=3.734±0.936 at 25 °C (Cayman, 2021b).

Metonitazene free base has a solubility in dimethylformamide (DMF) of 25 mg/mL and of 20 mg/mL in dimethyl sulfoxide (DMSO).

In a mixture of DMF and phosphate-buffered saline (PBS) DMF:PBS (pH 7.2) (1:1), the free base is soluble at 0.5 mg/mL and at 10 mg/mL in ethanol (Cayman, 2021b).

Metonitazene citrate is soluble in DMF and DMSO at 10 mg/mL and at 1 mg/mL in PBS (pH 7.2) (Cayman, 2021a).


Related Products

Produced strong analgesic effects with varying potencies:

butonitazene, etodesnitazene, etonitazepipne, etonitazepyne, flunitazene, metodesnitazene, protonitazene

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