No matter what kind of cancer it is, it will have pain of varying degrees after it develops to the middle and late stages, presenting dull pain like knife cutting and acupuncture pain, which will affect daily work and life, and also increase the psychological burden of patients, or even give up treatment. With regard to cancer pain, many patients go wrong, not only making the body suffer, but also making the disease worse.
Pain is the fifth vital sign after heart rate, blood pressure, pulse and respiration. Pain has received more and more clinical attention. Its definition has been updated as “pain is an unpleasant feeling and emotional experience related to the actual or potential tissue damage, or the description of such damage, including the painful experience of feeling, emotion, cognition and social elements.” Through this definition, the connotation of cancer pain is no longer limited to the clinical level, but also expanded to the level of patients’ cognitive and social functions, Therefore, the administration and management of cancer pain is very important.
In China, moderate to severe cancer pain exists in about 70%~80% of patients with advanced cancer. Although we have realized the importance of analgesic treatment in recent years, some investigative and observational research results show that the use of opioids in China is still obviously insufficient at this stage, and many patients are suffering from pain or severe pain without effective control.
What are the misconceptions about cancer pain?
Control cancer before relieving pain
For cancer pain patients, the treatment of cancer is as important as pain relief. Cancer pain is easy to occur when the cancer develops to the middle and late stages. However, the treatment effect of the middle and late stage cancer is limited, and the effect is not ideal only by treating cancer to relieve pain.
With the further development of cancer, the pain problem will be gradually aggravated; In turn, pain can affect the progress of cancer treatment. Early scientific and standardized pain relief can effectively improve the quality of life of patients, improve treatment compliance, enhance resistance, help establish confidence in overcoming diseases, and thus extend the survival period.
The pain of some patients is related to neuropathy, which is caused by nerve damage and has nothing to do with sterile inflammatory stimulation. Even though the cancer can be controlled, the nerve damage can not be recovered, and the pain still lasts for a lifetime.
Take painkillers only when you are in pain
As with other chronic diseases, cancer pain can be stabilized by using drugs on time and in proper amount to help stabilize the condition and relieve pain. If you take less medicine because of some factors, you need to increase the amount of medicine to control the pain next time and increase the side effects on your body. In a word, it is necessary to increase or reduce the dosage scientifically under the guidance of doctors; If you feel the pain is well controlled, you may wish to ask a professional doctor to assess whether you need to reduce or stop the medication. Sudden withdrawal of painkillers may aggravate the pain, so be careful.
Safety of taking non opioid drugs
Many patients believe that opioids are addictive. In fact, the addiction to opioids is very low. With the further development of cancer, the degree of pain becomes more and more severe, and the amount of analgesic drugs taken has also increased. In addition, opioids are tolerable. Most patients use more and more drugs. This is a normal phenomenon, different from addiction. Opioids should be the first choice for patients with chronic cancer pain and those who need to take painkillers for a long time.
Give up directly due to poor effect after taking multiple drugs
Cancer pain treatment is divided into two aspects. On the one hand, it is to receive anti-tumor treatment, including surgical resection, radiotherapy or chemotherapy, targeted drug therapy, microwave or radio frequency ablation, etc; On the one hand, there are three steps of drug therapy. In addition, there are many ways to relieve pain, such as nerve destruction or nerve block, as well as self-control analgesia, infusion of analgesics, etc. These pain relief techniques are less invasive to the body and have good therapeutic effects. If the pain can not be controlled after taking multiple drugs, the above pain relief techniques can be selected, and the effective rate can reach about 90%.
At present, the three-step classification of cancer pain drugs is still the basis of cancer pain treatment. Opioids are the basic drugs for the treatment of moderate and severe cancer pain. The general principle is that oral administration is the first choice for long-term use of opioids, and other routes of administration include intravenous, subcutaneous, rectal and percutaneous administration. The drug should be administered on time, that is, at regular intervals, to maintain a stable and effective blood concentration.
The existing evidence is not enough to recommend a specific opioid drug for initial treatment. Long acting or short acting drugs should be preferred, as well as the specific administration scheme. The general principle is that patients who do not tolerate opioids should start from a small dose if they are weak and older. The immediate release preparation is the first choice for treatment, and the dosage is gradually increased to produce curative effect. Meanwhile, be alert to whether side effects occur. The dosage used for 24 hours was then converted into a sustained-release preparation, which was administered twice a day according to the time. If the patient has explosive pain, use immediate release preparation to relieve it. Specific opioid titration process (simplified process of using sustained release oxycodone) and dosage.
Opioids are a large class of drugs with relatively strong analgesic effects, mainly acting on opioid receptors in the central nervous system. According to the different opioid receptors that opioid analgesics act on, they can be divided into two categories: opioid receptor agonists and opioid receptor agonists antagonists. Although they have strong analgesic effects, long-term use will also lead to some side effects, which need attention.
When our human body is subjected to some serious physical stimulation, such as burns, scalds, bruises, etc., our first feeling is pain. Sometimes pain can make people have a stress reaction to escape from danger, but sometimes pain reaction can make a person miserable, or even lead to painful shock. At this time, pain relief is very necessary. Opioid analgesics is a kind of drug with powerful analgesic effect, which will be briefly described in this paper.
Opioids are a large class of drugs with strong analgesic effects, mainly acting on opioid receptors in the center, thus blocking the pain conduction of patients and having analgesic effects. However, excessive use of opioids can produce certain side effects.
According to the different opioid receptors that opioid analgesics act on, they can be divided into opioid receptor agonists and opioid receptor agonists antagonists. Among them, opioid receptor agonists mainly include morphine and so on, which are familiar to us. This kind of drugs mainly act on the u receptor. When the u receptor is excited, the pain conduction will also be blocked, which will also lead to a sense of euphoria in the brain, so as to achieve its analgesic effect.
Another type of opioid analgesics is opioid receptor agonist antagonist, and the main representative drug is pentazocin. Opioid drugs of this kind are exciting κ Receptors and Blocking μ The effect of the receptor, however, is worse than that of morphine in terms of analgesic effect and addiction. This kind of drugs are mainly used for various chronic pain, which is also related to the low risk of long-term addiction.
Through the above brief introduction, we should have known about the main classification of opioid receptors. Although opioid analgesics have strong analgesic effects, long-term use will also lead to some side effects, such as drug addiction, thinking disorders and hallucinations, which need attention. For patients, this kind of medicine cannot be taken without authorization, and should be taken according to the doctor’s advice.
The painkiller containing cas 1468051 4 and cas 119276 016 is a very effective analgesic, and will not have side effects on our bodies. It would be wise to choose it to relieve pain.